Piper moves to Santa Cruz, California to go to the Institute of Art. When she was 15 she gave birth to a daughter, but had to put her up for adoption because she was too young to raise her. Years later she sees an article about a girl she thinks is her daughter, who lives in Santa Cruz, and applies for a job in a sandwich shop. As she works there she gets to know the staff. Tish is a babe, she tries to seduce every guy who comes into the shop, and she goes home with those who flirt back. Jen, a computer nerd who has a love affair online with a guy who calls himself fuzzy22. She's not as pretty as Tish and she struggles with self-confidence. And there's a crazy haired guy called Priestly; he's not like other guys and dresses different then everyone because he refuses to be "another clone". Piper's boss is a really nice guy named Trucker, who's in love with a woman who own the store across the street...

For three college guys, it's senior year and the co-ed experience has left them high and dry. Their solution: A road trip to Mardi Gras, where beautiful babes are happy to lift their shirts and open containers are always welcome. But after dressing in drag, breaking into Carmen Electra's hotel room, starring in a scandalous sex show and accidentally exploding a feces bomb in a swank hotel lobby, will the Mardi Gras magic kick in and their wildest fantasies come true?

Fresh from Des Moines, Iowa, Sara has just landed in Los Angeles as a college freshman studying fashion design. She meets handsome Stephen, party-lover Tracy, and roommate Rebecca. Rebecca is nice, sweet and ready to share everything with Sara. It could be the beginning of a beautiful friendship. But Tracy is convinced that there's something seriously wrong with Rebecca and bad things start happening to everyone close to Sara. If Sara is to have a normal college experience, she's going to have to get to the bottom of what's up with Rebecca and quickly get out of her clutches.

Two guys, Nick and Shawn decide a two week stint at a Cheerleaders' Camp is the perfect opportunity to score tons of meaningless romantic liaisons with lonely girls in tight-tops and short-short skirts. But their lusty plan to caress as many pom-poms as possible goes awry when one of the dudes fall in love.

The morning they return from their White Castle road trip, Harold and Kumar decide to go to Amsterdam because Harold doesn't want to wait ten days to see Maria again. On the plane, Kumar lights up his new bong, the air marshals think it's a bomb, and Harold and Kumar are arrested as terrorists and sent to Guantanamo Bay. Ordered to fellate a guard, they manage to escape, make their way to Florida, and head for Texas to find Kumar's ex-girlfriend's fiancé, the well-connected Colton, and get him to intercede with Washington on their behalf. Kumar still has a thing for Vanessa, the feds are in hot pursuit, and the legal weed of Amsterdam seems a long way away.